Piotr Hadaczek, PhD

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[email protected]
+1 415 476-1125

My research experience has been focused for many years on translational neuroscience. I have participated extensively in the creation of novel approaches for the delivery of therapeutic agents to specific target regions within the brain to develop effective treatments for brain diseases. In addition, I have developed release assays for clinical gene therapy products, and I am an expert on analytical method development and optimization. I have run and supervised many projects (preclinical studies) that, with the help of industry partners (Avigen, Genzyme), culminated in a clinical trial at UCSF and another at NIH. In that context, I have acquired considerable expertise in the supervision of technical staff and managing small research groups. I am very confident in my ability to direct R&D programs in the neuroscience (Parkinson’s disease) and oncology (brain tumor) fields. My main interest has been in the treatment of Parkinson’s disease via gene transfer and direct infusion of neurotrophic factors to counter neurodegeneration, and it is the area in which I have published many of my papers.

Publications: 

Validation of antibodies for neuroanatomical localization of the P2Y11 receptor in macaque brain.

Journal of chemical neuroanatomy

Dreisig K, Degn M, Sund L, Hadaczek P, Samaranch L, San Sebastian W, Bankiewicz K, Rahbek Kornum B

Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease.

Molecular therapy. Methods & clinical development

Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Samaranch L, Pivirotto P, Bringas J, O'Riordan C, Mastis B, San Sebastian W, Forsayeth J, Cheng SH, Bankiewicz KS, Shihabuddin LS

Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response.

Gene therapy

Samaranch L, Hadaczek P, Kells AP, Bringas JR, Stockinger D, San Sebastian W, Macayan M, Samineni S, Pivirotto P, Forsayeth J, Bankiewicz KS

Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma.

Cancer research

Soroceanu L, Matlaf L, Khan S, Akhavan A, Singer E, Bezrookove V, Decker S, Ghanny S, Hadaczek P, Bengtsson H, Ohlfest J, Luciani-Torres MG, Harkins L, Perry A, Guo H, Soteropoulos P, Cobbs CS

GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.

Experimental neurology

Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW

SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE.

Molecular therapy. Methods & clinical development

San Sebastian W, Kells AP, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, Macayan M, Pivirotto PJ, Forsayeth J, Osborne S, Wright JF, Green F, Heller G, Bankiewicz KS

The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease.

Pharmacological reports : PR

Joniec-Maciejak I, Ciesielska A, Wawer A, Sznejder-Pacholek A, Schwenkgrub J, Cudna A, Hadaczek P, Bankiewicz KS, Czlonkowska A, Czlonkowski A

Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy.

Frontiers in neuroanatomy

Salegio EA, Streeter H, Dube N, Hadaczek P, Samaranch L, Kells AP, San Sebastian W, Zhai Y, Bringas J, Xu T, Forsayeth J, Bankiewicz KS

Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors.

Nanomedicine (London, England)

Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW

Cidofovir: a novel antitumor agent for glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Hadaczek P, Ozawa T, Soroceanu L, Yoshida Y, Matlaf L, Singer E, Fiallos E, James CD, Cobbs CS

Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses.

Molecular therapy : the journal of the American Society of Gene Therapy

Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J

Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study.

Journal of neuro-oncology

Mendiburu-Eliçabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS

Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system.

PloS one

Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS

Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion.

Experimental neurology

Ziegler RJ, Salegio EA, Dodge JC, Bringas J, Treleaven CM, Bercury SD, Tamsett TJ, Shihabuddin L, Hadaczek P, Fiandaca M, Bankiewicz K, Scheule RK

Anterograde axonal transport of AAV2-GDNF in rat basal ganglia.

Molecular therapy : the journal of the American Society of Gene Therapy

Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS

Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders.

Human gene therapy

Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS

Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS

Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors.

Molecular therapy : the journal of the American Society of Gene Therapy

Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS

Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.

Molecular therapy : the journal of the American Society of Gene Therapy

Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS

Image-guided convection-enhanced delivery of GDNF protein into monkey putamen.

NeuroImage

Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS

Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.

Human gene therapy

Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS

Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience.

Journal of neuro-oncology

Grahn AY, Bankiewicz KS, Dugich-Djordjevic M, Bringas JR, Hadaczek P, Johnson GA, Eastman S, Luz M

Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys.

Human gene therapy

Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS

Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response.

Human gene therapy

Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS

Efficient gene therapy-based method for the delivery of therapeutics to primate cortex.

Proceedings of the National Academy of Sciences of the United States of America

Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS

Controlled dissemination of AAV vectors in the primate brain.

Progress in brain research

Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS

Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.

NeuroImage

Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS

Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J

The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.

Molecular therapy : the journal of the American Society of Gene Therapy

Hadaczek P, Yamashita Y, Mirek H, Tamas L, Bohn MC, Noble C, Park JW, Bankiewicz K

Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain.

Human gene therapy

Hadaczek P, Kohutnicka M, Krauze MT, Bringas J, Pivirotto P, Cunningham J, Bankiewicz K

Cytogenetic and molecular findings in 75 clear cell renal cell carcinomas.

Oncology reports

Kardas I, Mrózek K, Babinska M, Krajka K, Hadaczek P, Lubinski J, Roszkiewicz A, Kuziemska E, Limon J

Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery.

Journal of neuro-oncology

Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, Drummond DC, Hong K, Kirpotin DB, McKnight T, Berger MS, Park JW, Bankiewicz KS

Detection of germline mutations in the BRCA1 gene by RNA-based sequencing.

Human mutation

Jakubowska A, Górski B, Byrski T, Huzarski T, Gronwald J, Menkiszak J, Cybulski C, Debniak T, Hadaczek P, Scott RJ, Lubinski J

Optimization of experimental conditions for RNA-based sequencing of MLH1 and MSH2 genes.

Human mutation

Jakubowska A, Górski B, Kurzawski G, Debniak T, Hadaczek P, Cybulski C, Kladny J, Oszurek O, Scott RJ, Lubinski J

Fhit protein expression in endometrial cancers: no correlation with histological grade.

Polish journal of pathology : official journal of the Polish Society of Pathologists

Hadaczek P, Gronwald J, Chosia M, Huebner K, Lubinski J

Fhit protein expression in hereditary and sporadic colorectal cancers.

Polish journal of pathology : official journal of the Polish Society of Pathologists

Hadaczek P, Debniak T, Kurzawski G, Jakubowska A, Huzarski T, Huebner K, Lubinski J

Fhit expression is absent or reduced in a subset of primary head and neck cancer.

Anticancer research

Götte K, Hadaczek P, Coy JF, Wirtz HW, Riedel F, Neubauer J, Hörmann K

Loss or reduction of Fhit expression in renal neoplasias: correlation with histogenic class.

Human pathology

Hadaczek P, Kovatich A, Gronwald J, Lubinski J, Huebner K, McCue PA

Molecular evidence for derivation of metastatic cells from minor subclones of primary clear renal cell carcinomas.

Cancer detection and prevention

Gronwald J, Hadaczek P, Störkel S, Holtgreve-Grez H, Rabbitts P, Cremer T, Lubinski J

Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors.

Cancer

Kovatich A, Friedland DM, Druck T, Hadaczek P, Huebner K, Comis RL, Hauck W, McCue PA

Absence or reduction of Fhit expression in most clear cell renal carcinomas.

Cancer research

Hadaczek P, Siprashvili Z, Markiewski M, Domagala W, Druck T, McCue PA, Pekarsky Y, Ohta M, Huebner K, Lubinski J

The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.

Biochimica et biophysica acta

Huebner K, Hadaczek P, Siprashvili Z, Druck T, Croce CM

Structure and expression of the human FHIT gene in normal and tumor cells.

Cancer research

Druck T, Hadaczek P, Fu TB, Ohta M, Siprashvili Z, Baffa R, Negrini M, Kastury K, Veronese ML, Rosen D, Rothstein J, McCue P, Cotticelli MG, Inoue H, Croce CM, Huebner K

Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: importance of 1q and 3p copy number changes in metastatic events.

Cancer research

Gronwald J, Störkel S, Holtgreve-Grez H, Hadaczek P, Brinkschmidt C, Jauch A, Lubinski J, Cremer T

Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas.

Cancer research

Druck T, Kastury K, Hadaczek P, Podolski J, Toloczko A, Sikorski A, Ohta M, LaForgia S, Lasota J, McCue P

Non-isotopic procedure with silver staining of polyacrylamide gels in detection of genomic abnormalities in tumors using microsatellites.

Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society

Podolski J, Hadaczek P, Gibas Z, Gibas L, Grossman HB, Limon J, Huebner K, Lubinski J

Environmental factors may regulate BCL2 associated lymphomagenesis: a very low incidence of BCL2-MBR translocation in Poland.

Polish journal of pathology : official journal of the Polish Society of Pathologists

Lubinski J, Podolski J, Hadaczek P, Mioduszewska O, Rylski M, Huebner K

Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas.

Cancer research

Lubinski J, Hadaczek P, Podolski J, Toloczko A, Sikorski A, McCue P, Druck T, Huebner K

[Detection of tumor virus infections with HPV 16, 18, and 33 from cytologic material in the uterine neck using the PCR method].

Ginekologia polska

Podolski J, Hadaczek P, Cpbulski C, Rylski M, Sumera K, Sowinska E, Uznanski B, Rzepka-Górska I, Lubinski J

[HPV virus infections and other promotion factors of the carcinogenic process in girls].

Ginekologia polska

Rzepka-Górska I, Blogowska A, Zielinska D, Lubinski J, Podolski J, Hadaczek P, Górski B, Debniak T