Krystof Bankiewicz, MD, PhD

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Dr. Krystof Bankiewicz holds an M.D. from Jagiellonian University in Crakow and a Ph.D., D.Sc. from the Institute of Neurology and Psychiatry in Warsaw, Poland and Professor title by the President of Republic of Poland. Dr. Bankiewicz was a recipient of Fogarty Fellowship and trained at the National Institutes of Neurological Disorders and Stroke at NIH, Bethesda, MD.
Dr. Krystof Bankiewicz is an expert in local delivery of therapeutics to the brain as well as gene therapy and has brought multiple drug and gene therapies to the clinic. He is the Kinetics Foundation Chair in Translational Research and Professor in Residence of Neurological Surgery and Neurology at the University of California at San Francisco. Dr. Bankiewicz is also Vice Chair for Research in the Department of Neurosurgery and Director of Interventional Neurology Center at UCSF. Dr. Bankiewicz has both industry and academic experience, is an inventor on numerous patents and has published more than 180 peer-reviewed research articles. He has considerable experience in supervising multi-investigator translational programs and is a principal investigator on several multi-center, multi-investigator grants and clinical trials. He has supervised a total of 35 postdoctoral fellows and manages a core research group of 20 people, including technicians, postdoctoral fellows and senior scientists. Throughout his career, Dr. Bankiewicz has maintained a strong focus on the development of translational approaches to drug, gene and cell replacement therapies, and he has displayed the ability to synthesize distinct technologies into powerful new approaches to the treatment of serious diseases, including brain cancer, Parkinson's disease, Huntington’s disease, Alzheimer’s diseases, pediatric neurotransmitter deficiency and lysosomal storage disorders.

Publications: 

Gene therapy for Parkinson's disease: contemporary practice and emerging concepts.

Expert review of neurotherapeutics

Merola A, Van Laar A, Lonser R, Bankiewicz K

AAV viral vector delivery to the brain by shape-conforming MR-guided infusions.

Journal of controlled release : official journal of the Controlled Release Society

Bankiewicz KS, Sudhakar V, Samaranch L, San Sebastian W, Bringas J, Forsayeth J

Translational fidelity of intrathecal delivery of self-complementary AAV9-survival motor neuron 1 for spinal muscular atrophy.

Human gene therapy

Passini MA, Bu J, Richards AM, Treleaven CM, Sullivan JA, O'Riordan CR, Scaria A, Kells AP, Samaranch L, San Sebastian W, Federici T, Fiandaca MS, Boulis NM, Bankiewicz KS, Shihabuddin LS, Cheng SH

Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors.

Nanomedicine (London, England)

Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW

Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate.

Journal of neural engineering

Ryapolova-Webb E, Afshar P, Stanslaski S, Denison T, de Hemptinne C, Bankiewicz K, Starr PA

AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction.

Molecular therapy : the journal of the American Society of Gene Therapy

Samaranch L, Sebastian WS, Kells AP, Salegio EA, Heller G, Bringas JR, Pivirotto P, DeArmond S, Forsayeth J, Bankiewicz KS

Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain.

Magnetic resonance in medicine

Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ

Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers.

Biomacromolecules

Dube N, Shu JY, Dong H, Seo JW, Ingham E, Kheirolomoom A, Chen PY, Forsayeth J, Bankiewicz K, Ferrara KW, Xu T

Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain.

Gene therapy

San Sebastian W, Samaranch L, Heller G, Kells AP, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS

Gene therapy for misfolding protein diseases of the central nervous system.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

San Sebastian W, Samaranch L, Kells AP, Forsayeth J, Bankiewicz KS

Automated segmentation tool for brain infusions.

PloS one

Rosenbluth KH, Gimenez F, Kells AP, Salegio EA, Mittermeyer GM, Modera K, Kohal A, Bankiewicz KS

Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model.

Cancer gene therapy

Yin D, Zhai Y, Gruber HE, Ibanez CE, Robbins JM, Kells AP, Kasahara N, Forsayeth J, Jolly DJ, Bankiewicz KS

Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates.

Human gene therapy

Samaranch L, Salegio EA, San Sebastian W, Kells AP, Bringas JR, Forsayeth J, Bankiewicz KS

Rapid inverse planning for pressure-driven drug infusions in the brain.

PloS one

Rosenbluth KH, Martin AJ, Mittermeyer S, Eschermann J, Dickinson PJ, Bankiewicz KS

Advances in thin tissue Golgi-Cox impregnation: fast, reliable methods for multi-assay analyses in rodent and non-human primate brain.

Journal of neuroscience methods

Levine ND, Rademacher DJ, Collier TJ, O'Malley JA, Kells AP, San Sebastian W, Bankiewicz KS, Steece-Collier K

Effect of human interleukin-10 on the expression of nitric oxide synthases in the MPTP-based model of Parkinson's disease.

Pharmacological reports : PR

Schwenkgrub J, Joniec-Maciejak I, Sznejder-Pacholek A, Wawer A, Ciesielska A, Bankiewicz K, Czlonkowska A, Czlonkowski A

Comparing routes of delivery for nanoliposomal irinotecan shows superior anti-tumor activity of local administration in treating intracranial glioblastoma xenografts.

Neuro-oncology

Chen PY, Ozawa T, Drummond DC, Kalra A, Fitzgerald JB, Kirpotin DB, Wei KC, Butowski N, Prados MD, Berger MS, Forsayeth JR, Bankiewicz K, James CD

Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses.

Molecular therapy : the journal of the American Society of Gene Therapy

Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J

Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 Tesla MRI.

Journal of magnetic resonance imaging : JMRI

Rosenbluth KH, Martin AJ, Bringas J, Bankiewicz KS

Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain.

Human gene therapy

Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J

Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type A.

Molecular therapy : the journal of the American Society of Gene Therapy

Bu J, Ashe KM, Bringas J, Marshall J, Dodge JC, Cabrera-Salazar MA, Forsayeth J, Schuchman EH, Bankiewicz KS, Cheng SH, Shihabuddin LS, Passini MA

Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications.

Pharmaceuticals (Basel, Switzerland)

Fiandaca MS, Bankiewicz KS, Federoff HJ

Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease.

Human gene therapy

Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kaplan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS

Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates.

Human gene therapy

Samaranch L, Salegio EA, San Sebastian W, Kells AP, Foust KD, Bringas JR, Lamarre C, Forsayeth J, Kaspar BK, Bankiewicz KS

Axonal transport of adeno-associated viral vectors is serotype-dependent.

Gene therapy

Salegio EA, Samaranch L, Kells AP, Mittermeyer G, San Sebastian W, Zhou S, Beyer J, Forsayeth J, Bankiewicz KS

Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study.

Journal of neuro-oncology

Mendiburu-Eliçabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS

Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum.

Human gene therapy

San Sebastian W, Richardson RM, Kells AP, Lamarre C, Bringas J, Pivirotto P, Salegio EA, Dearmond SJ, Forsayeth J, Bankiewicz KS

Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system.

PloS one

Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS

Guided delivery of adeno-associated viral vectors into the primate brain.

Advanced drug delivery reviews

Salegio EA, Samaranch L, Kells AP, Forsayeth J, Bankiewicz K

Analysis of a simulation algorithm for direct brain drug delivery.

NeuroImage

Rosenbluth KH, Eschermann JF, Mittermeyer G, Thomson R, Mittermeyer S, Bankiewicz KS

Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion.

Experimental neurology

Ziegler RJ, Salegio EA, Dodge JC, Bringas J, Treleaven CM, Bercury SD, Tamsett TJ, Shihabuddin L, Hadaczek P, Fiandaca M, Bankiewicz K, Scheule RK

T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery.

Neurosurgery

Richardson RM, Gimenez F, Salegio EA, Su X, Bringas J, Berger MS, Bankiewicz KS

AAV9: over the fence and into the woods . . .

Molecular therapy : the journal of the American Society of Gene Therapy

Forsayeth JR, Bankiewicz KS

Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain.

Stereotactic and functional neurosurgery

Richardson RM, Kells AP, Martin AJ, Larson PS, Starr PA, Piferi PG, Bates G, Tansey L, Rosenbluth KH, Bringas JR, Berger MS, Bankiewicz KS

Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS

Design of an in-dwelling cannula for convection-enhanced delivery.

Journal of neuroscience methods

Rosenbluth KH, Luz M, Mohr E, Mittermeyer S, Bringas J, Bankiewicz KS

Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements.

Journal of neuroscience methods

Fiandaca MS, Salegio EA, Yin D, Richardson RM, Valles FE, Larson PS, Starr PA, Lonser RR, Bankiewicz KS

An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Laganiere J, Kells AP, Lai JT, Guschin D, Paschon DE, Meng X, Fong LK, Yu Q, Rebar EJ, Gregory PD, Bankiewicz KS, Forsayeth J, Zhang HS

Gene therapy for Parkinson's disease: where are we now and where are we going?

Expert review of neurotherapeutics

Forsayeth J, Bankiewicz KS, Aminoff MJ

Anterograde axonal transport of AAV2-GDNF in rat basal ganglia.

Molecular therapy : the journal of the American Society of Gene Therapy

Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS

Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease.

Neurosurgery

Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS

Gene therapy for Parkinson's disease: from non-human primates to humans.

Current opinion in molecular therapeutics

Fiandaca MS, Bankiewicz KS

Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders.

Human gene therapy

Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS

Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics.

Journal of neurosurgery

Yin D, Richardson RM, Fiandaca MS, Bringas J, Forsayeth J, Berger MS, Bankiewicz KS

Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS

Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors.

Molecular therapy : the journal of the American Society of Gene Therapy

Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS

Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.

Molecular therapy : the journal of the American Society of Gene Therapy

Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS

Ultrasound-enhanced drug transport and distribution in the brain.

AAPS PharmSciTech

Liu Y, Paliwal S, Bankiewicz KS, Bringas JR, Heart G, Mitragotri S, Prausnitz MR

Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells.

Gene therapy

Kato T, Natsume A, Toda H, Iwamizu H, Sugita T, Hachisu R, Watanabe R, Yuki K, Motomura K, Bankiewicz K, Wakabayashi T

Canine spontaneous glioma: a translational model system for convection-enhanced delivery.

Neuro-oncology

Dickinson PJ, LeCouteur RA, Higgins RJ, Bringas JR, Larson RF, Yamashita Y, Krauze MT, Forsayeth J, Noble CO, Drummond DC, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS

Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats.

Cell stem cell

Martínez-Cerdeño V, Noctor SC, Espinosa A, Ariza J, Parker P, Orasji S, Daadi MM, Bankiewicz K, Alvarez-Buylla A, Kriegstein AR

Image-guided convection-enhanced delivery of GDNF protein into monkey putamen.

NeuroImage

Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS

Optimized cannula design and placement for convection-enhanced delivery in rat striatum.

Journal of neuroscience methods

Yin D, Forsayeth J, Bankiewicz KS

Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals.

Stem cells and development

Yasuhara T, Matsukawa N, Hara K, Maki M, Ali MM, Yu SJ, Bae E, Yu G, Xu L, McGrogan M, Bankiewicz K, Case C, Borlongan CV

Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.

Human gene therapy

Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease.

Neurology

Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ

Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates.

NeuroImage

Yin D, Valles FE, Fiandaca MS, Bringas J, Gimenez F, Berger MS, Forsayeth J, Bankiewicz KS

Anatomic compression caused by high-volume convection-enhanced delivery to the brain.

Neurosurgery

Valles F, Fiandaca MS, Bringas J, Dickinson P, LeCouteur R, Higgins R, Berger M, Forsayeth J, Bankiewicz KS

Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience.

Journal of neuro-oncology

Grahn AY, Bankiewicz KS, Dugich-Djordjevic M, Bringas JR, Hadaczek P, Johnson GA, Eastman S, Luz M

Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys.

Human gene therapy

Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS

Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys.

Human gene therapy

Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS

Future applications: gene therapy.

Neurosurgery clinics of North America

Richardson RM, Varenika V, Forsayeth JR, Bankiewicz KS

Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response.

Human gene therapy

Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS

Efficient gene therapy-based method for the delivery of therapeutics to primate cortex.

Proceedings of the National Academy of Sciences of the United States of America

Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS

Controlled dissemination of AAV vectors in the primate brain.

Progress in brain research

Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS

Convection-enhanced delivery of liposomes to primate brain.

Methods in enzymology

Krauze MT, Forsayeth J, Yin D, Bankiewicz KS

Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.

NeuroImage

Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS

Convection-enhanced delivery of polyethylene glycol-coated liposomal doxorubicin: characterization and efficacy in rat intracranial glioma models.

Journal of neurosurgery

Kikuchi T, Saito R, Sugiyama S, Yamashita Y, Kumabe T, Krauze M, Bankiewicz K, Tominaga T

Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery.

Journal of neurosurgery

Varenika V, Dickinson P, Bringas J, LeCouteur R, Higgins R, Park J, Fiandaca M, Berger M, Sampson J, Bankiewicz K

Striatal volume differences between non-human and human primates.

Journal of neuroscience methods

Yin D, Valles FE, Fiandaca MS, Forsayeth J, Larson P, Starr P, Bankiewicz KS

Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum.

Molecular therapy : the journal of the American Society of Gene Therapy

Herzog CD, Dass B, Gasmi M, Bakay R, Stansell JE, Tuszynski M, Bankiewicz K, Chen EY, Chu Y, Bishop K, Kordower JH, Bartus RT

Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J

Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain.

Molecular therapy : the journal of the American Society of Gene Therapy

Cunningham J, Pivirotto P, Bringas J, Suzuki B, Vijay S, Sanftner L, Kitamura M, Chan C, Bankiewicz KS

Canine model of convection-enhanced delivery of liposomes containing CPT-11 monitored with real-time magnetic resonance imaging: laboratory investigation.

Journal of neurosurgery

Dickinson PJ, LeCouteur RA, Higgins RJ, Bringas JR, Roberts B, Larson RF, Yamashita Y, Krauze M, Noble CO, Drummond D, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease.

Neurology

Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ

PET 6-[F]fluoro-L-m-tyrosine Studies of Dopaminergic Function in Human and Nonhuman Primates.

Frontiers in human neuroscience

Eberling JL, Bankiewicz KS, O'Neil JP, Jagust WJ

Image-guided convection-enhanced delivery platform in the treatment of neurological diseases.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Fiandaca MS, Forsayeth JR, Dickinson PJ, Bankiewicz KS

Safety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective.

Experimental neurology

Krauze MT, Vandenberg SR, Yamashita Y, Saito R, Forsayeth J, Noble C, Park J, Bankiewicz KS

The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys.

Experimental neurology

Eberling JL, Pivirotto P, Bringas J, Steiner JP, Kordower JH, Chu Y, Emborg ME, Bankiewicz KS

Preclinical models of Parkinson's disease.

Current protocols in neuroscience

Bankiewicz KS, Sanchez-Pernaute R, Oiwa Y, Kohutnicka M, Cummins A, Eberling J