John Forsayeth, PhD

Recall Faculty
Neurological Surgery
+1 415 902-4076
Publications: 

GDNF gene therapy for alcohol use disorder in male non-human primates.

Nature medicine

Ford MM, George BE, Van Laar VS, Holleran KM, Naidoo J, Hadaczek P, Vanderhooft LE, Peck EG, Dawes MH, Ohno K, Bringas J, McBride JL, Samaranch L, Forsayeth JR, Jones SR, Grant KA, Bankiewicz KS

Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.

Brain, behavior, and immunity

Watkins LR, Chavez RA, Landry R, Fry M, Green-Fulgham SM, Coulson JD, Collins SD, Glover DK, Rieger J, Forsayeth JR

Adeno-associated viral vector serotype 9-based gene therapy for Niemann-Pick disease type A.

Science translational medicine

Samaranch L, Pérez-Cañamás A, Soto-Huelin B, Sudhakar V, Jurado-Arjona J, Hadaczek P, Ávila J, Bringas JR, Casas J, Chen H, He X, Schuchman EH, Cheng SH, Forsayeth J, Bankiewicz KS, Ledesma MD

Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates.

Molecular therapy. Methods & clinical development

Ohno K, Samaranch L, Hadaczek P, Bringas JR, Allen PC, Sudhakar V, Stockinger DE, Snieckus C, Campagna MV, San Sebastian W, Naidoo J, Chen H, Forsayeth J, Salegio EA, Hwa GGC, Bankiewicz KS

Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS.

Molecular therapy : the journal of the American Society of Gene Therapy

Naidoo J, Stanek LM, Ohno K, Trewman S, Samaranch L, Hadaczek P, O'Riordan C, Sullivan J, San Sebastian W, Bringas JR, Snieckus C, Mahmoodi A, Mahmoodi A, Forsayeth J, Bankiewicz KS, Shihabuddin LS

Ganglioside Metabolism and Parkinson's Disease.

Frontiers in neuroscience

Forsayeth J, Hadaczek P

Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity.

Stroke

Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H

Depletion of AADC activity in caudate nucleus and putamen of Parkinson's disease patients; implications for ongoing AAV2-AADC gene therapy trial.

PloS one

Ciesielska A, Samaranch L, San Sebastian W, Dickson DW, Goldman S, Forsayeth J, Bankiewicz KS

Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease.

Molecular therapy. Methods & clinical development

Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Samaranch L, Pivirotto P, Bringas J, O'Riordan C, Mastis B, San Sebastian W, Forsayeth J, Cheng SH, Bankiewicz KS, Shihabuddin LS

Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.

Brain, behavior, and immunity

Grace PM, Loram LC, Christianson JP, Strand KA, Flyer-Adams JG, Penzkover KR, Forsayeth JR, van Dam AM, Mahoney MJ, Maier SF, Chavez RA, Watkins LR

Axonal transport of AAV9 in nonhuman primate brain.

Gene therapy

Green F, Samaranch L, Zhang HS, Manning-Bog A, Meyer K, Forsayeth J, Bankiewicz KS

AAV viral vector delivery to the brain by shape-conforming MR-guided infusions.

Journal of controlled release : official journal of the Controlled Release Society

Bankiewicz KS, Sudhakar V, Samaranch L, San Sebastian W, Bringas J, Forsayeth J

Cerebellomedullary Cistern Delivery for AAV-Based Gene Therapy: A Technical Note for Nonhuman Primates.

Human gene therapy methods

Samaranch L, Bringas J, Pivirotto P, Sebastian WS, Forsayeth J, Bankiewicz K

Self-assembled 20-nm (64)Cu-micelles enhance accumulation in rat glioblastoma.

Journal of controlled release : official journal of the Controlled Release Society

Seo JW, Ang J, Mahakian LM, Tam S, Fite B, Ingham ES, Beyer J, Forsayeth J, Bankiewicz KS, Xu T, Ferrara KW

Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response.

Gene therapy

Samaranch L, Hadaczek P, Kells AP, Bringas JR, Stockinger D, San Sebastian W, Macayan M, Samineni S, Pivirotto P, Forsayeth J, Bankiewicz KS

Transduction of antigen-presenting cells in the brain by AAV9 warrants caution in preclinical studies.

Molecular therapy : the journal of the American Society of Gene Therapy

Forsayeth J, Bankiewicz KS

GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.

Experimental neurology

Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW

SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE.

Molecular therapy. Methods & clinical development

San Sebastian W, Kells AP, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, Macayan M, Pivirotto PJ, Forsayeth J, Osborne S, Wright JF, Green F, Heller G, Bankiewicz KS

Peri-tumoral leakage during intra-tumoral convection-enhanced delivery has implications for efficacy of peri-tumoral infusion before removal of tumor.

Drug delivery

Yang X, Saito R, Nakamura T, Zhang R, Sonoda Y, Kumabe T, Forsayeth J, Bankiewicz K, Tominaga T

Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse.

Addiction biology

Barak S, Wang J, Ahmadiantehrani S, Ben Hamida S, Kells AP, Forsayeth J, Bankiewicz KS, Ron D

Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy.

Frontiers in neuroanatomy

Salegio EA, Streeter H, Dube N, Hadaczek P, Samaranch L, Kells AP, San Sebastian W, Zhai Y, Bringas J, Xu T, Forsayeth J, Bankiewicz KS

Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors.

Nanomedicine (London, England)

Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW

AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction.

Molecular therapy : the journal of the American Society of Gene Therapy

Samaranch L, Sebastian WS, Kells AP, Salegio EA, Heller G, Bringas JR, Pivirotto P, DeArmond S, Forsayeth J, Bankiewicz KS

Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers.

Biomacromolecules

Dube N, Shu JY, Dong H, Seo JW, Ingham E, Kheirolomoom A, Chen PY, Forsayeth J, Bankiewicz K, Ferrara KW, Xu T

Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain.

Gene therapy

San Sebastian W, Samaranch L, Heller G, Kells AP, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS

Gene therapy for misfolding protein diseases of the central nervous system.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

San Sebastian W, Samaranch L, Kells AP, Forsayeth J, Bankiewicz KS

Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model.

Cancer gene therapy

Yin D, Zhai Y, Gruber HE, Ibanez CE, Robbins JM, Kells AP, Kasahara N, Forsayeth J, Jolly DJ, Bankiewicz KS

Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates.

Human gene therapy

Samaranch L, Salegio EA, San Sebastian W, Kells AP, Bringas JR, Forsayeth J, Bankiewicz KS

Comparing routes of delivery for nanoliposomal irinotecan shows superior anti-tumor activity of local administration in treating intracranial glioblastoma xenografts.

Neuro-oncology

Chen PY, Ozawa T, Drummond DC, Kalra A, Fitzgerald JB, Kirpotin DB, Wei KC, Butowski N, Prados MD, Berger MS, Forsayeth JR, Bankiewicz K, James CD

Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses.

Molecular therapy : the journal of the American Society of Gene Therapy

Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J

Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain.

Human gene therapy

Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J

Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type A.

Molecular therapy : the journal of the American Society of Gene Therapy

Bu J, Ashe KM, Bringas J, Marshall J, Dodge JC, Cabrera-Salazar MA, Forsayeth J, Schuchman EH, Bankiewicz KS, Cheng SH, Shihabuddin LS, Passini MA

Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease.

Human gene therapy

Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kaplan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS

Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates.

Human gene therapy

Samaranch L, Salegio EA, San Sebastian W, Kells AP, Foust KD, Bringas JR, Lamarre C, Forsayeth J, Kaspar BK, Bankiewicz KS

Axonal transport of adeno-associated viral vectors is serotype-dependent.

Gene therapy

Salegio EA, Samaranch L, Kells AP, Mittermeyer G, San Sebastian W, Zhou S, Beyer J, Forsayeth J, Bankiewicz KS

Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study.

Journal of neuro-oncology

Mendiburu-Eliçabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS

Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum.

Human gene therapy

San Sebastian W, Richardson RM, Kells AP, Lamarre C, Bringas J, Pivirotto P, Salegio EA, Dearmond SJ, Forsayeth J, Bankiewicz KS

Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system.

PloS one

Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS

Guided delivery of adeno-associated viral vectors into the primate brain.

Advanced drug delivery reviews

Salegio EA, Samaranch L, Kells AP, Forsayeth J, Bankiewicz K

AAV9: over the fence and into the woods . . .

Molecular therapy : the journal of the American Society of Gene Therapy

Forsayeth JR, Bankiewicz KS

Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS

An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Laganiere J, Kells AP, Lai JT, Guschin D, Paschon DE, Meng X, Fong LK, Yu Q, Rebar EJ, Gregory PD, Bankiewicz KS, Forsayeth J, Zhang HS

Gene therapy for Parkinson's disease: where are we now and where are we going?

Expert review of neurotherapeutics

Forsayeth J, Bankiewicz KS, Aminoff MJ

Anterograde axonal transport of AAV2-GDNF in rat basal ganglia.

Molecular therapy : the journal of the American Society of Gene Therapy

Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS

Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease.

Neurosurgery

Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS

Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders.

Human gene therapy

Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS

Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics.

Journal of neurosurgery

Yin D, Richardson RM, Fiandaca MS, Bringas J, Forsayeth J, Berger MS, Bankiewicz KS

Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS

Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors.

Molecular therapy : the journal of the American Society of Gene Therapy

Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS

Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.

Molecular therapy : the journal of the American Society of Gene Therapy

Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS

Canine spontaneous glioma: a translational model system for convection-enhanced delivery.

Neuro-oncology

Dickinson PJ, LeCouteur RA, Higgins RJ, Bringas JR, Larson RF, Yamashita Y, Krauze MT, Forsayeth J, Noble CO, Drummond DC, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS

Image-guided convection-enhanced delivery of GDNF protein into monkey putamen.

NeuroImage

Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS

Optimized cannula design and placement for convection-enhanced delivery in rat striatum.

Journal of neuroscience methods

Yin D, Forsayeth J, Bankiewicz KS

Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.

Human gene therapy

Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS

Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates.

NeuroImage

Yin D, Valles FE, Fiandaca MS, Bringas J, Gimenez F, Berger MS, Forsayeth J, Bankiewicz KS

Anatomic compression caused by high-volume convection-enhanced delivery to the brain.

Neurosurgery

Valles F, Fiandaca MS, Bringas J, Dickinson P, LeCouteur R, Higgins R, Berger M, Forsayeth J, Bankiewicz KS

Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys.

Human gene therapy

Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS

Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys.

Human gene therapy

Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS

Future applications: gene therapy.

Neurosurgery clinics of North America

Richardson RM, Varenika V, Forsayeth JR, Bankiewicz KS

Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response.

Human gene therapy

Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS

Efficient gene therapy-based method for the delivery of therapeutics to primate cortex.

Proceedings of the National Academy of Sciences of the United States of America

Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS

Controlled dissemination of AAV vectors in the primate brain.

Progress in brain research

Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS

Convection-enhanced delivery of liposomes to primate brain.

Methods in enzymology

Krauze MT, Forsayeth J, Yin D, Bankiewicz KS

Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.

NeuroImage

Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS

Striatal volume differences between non-human and human primates.

Journal of neuroscience methods

Yin D, Valles FE, Fiandaca MS, Forsayeth J, Larson P, Starr P, Bankiewicz KS

Engineering GPCR signaling pathways with RASSLs.

Nature methods

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL

Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J

Image-guided convection-enhanced delivery platform in the treatment of neurological diseases.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Fiandaca MS, Forsayeth JR, Dickinson PJ, Bankiewicz KS

Safety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective.

Experimental neurology

Krauze MT, Vandenberg SR, Yamashita Y, Saito R, Forsayeth J, Noble C, Park J, Bankiewicz KS

Current status of gene therapy trials for Parkinson's disease.

Experimental neurology

Fiandaca M, Forsayeth J, Bankiewicz K

Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts.

Neuro-oncology

Krauze MT, Noble CO, Kawaguchi T, Drummond D, Kirpotin DB, Yamashita Y, Kullberg E, Forsayeth J, Park JW, Bankiewicz KS

Real-time imaging and quantification of brain delivery of liposomes.

Pharmaceutical research

Krauze MT, Forsayeth J, Park JW, Bankiewicz KS

Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.

Molecular therapy : the journal of the American Society of Gene Therapy

Bankiewicz KS, Forsayeth J, Eberling JL, Sanchez-Pernaute R, Pivirotto P, Bringas J, Herscovitch P, Carson RE, Eckelman W, Reutter B, Cunningham J

A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys.

Molecular therapy : the journal of the American Society of Gene Therapy

Forsayeth JR, Eberling JL, Sanftner LM, Zhen Z, Pivirotto P, Bringas J, Cunningham J, Bankiewicz KS

Distribution of AAV2-hAADC-transduced cells after 3 years in Parkinsonian monkeys.

Neuroreport

Daadi MM, Pivirotto P, Bringas J, Cunningham J, Forsayeth J, Eberling J, Bankiewicz KS

Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys.

Experimental neurology

Bankiewicz KS, Daadi M, Pivirotto P, Bringas J, Sanftner L, Cunningham J, Forsayeth JR, Eberling JL

Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging.

Brain research. Brain research protocols

Krauze MT, Mcknight TR, Yamashita Y, Bringas J, Noble CO, Saito R, Geletneky K, Forsayeth J, Berger MS, Jackson P, Park JW, Bankiewicz KS

Dimerizer regulation of AADC expression and behavioral response in AAV-transduced 6-OHDA lesioned rats.

Molecular therapy : the journal of the American Society of Gene Therapy

Sanftner LM, Rivera VM, Suzuki BM, Feng L, Berk L, Zhou S, Forsayeth JR, Clackson T, Cunningham J

Systemic administration of propentofylline does not attenuate morphine tolerance in non-injured rodents.

Neuroscience letters

Shumilla JA, Samuels I, Johnson KW, Forsayeth JR

Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen.

Experimental neurology

Krauze MT, Saito R, Noble C, Bringas J, Forsayeth J, McKnight TR, Park J, Bankiewicz KS

AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters.

Experimental neurology

Sanftner LM, Sommer JM, Suzuki BM, Smith PH, Vijay S, Vargas JA, Forsayeth JR, Cunningham J, Bankiewicz KS, Kao H, Bernal J, Pierce GF, Johnson KW

Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.

The European journal of neuroscience

Milligan ED, Langer SJ, Sloane EM, He L, Wieseler-Frank J, O'Connor K, Martin D, Forsayeth JR, Maier SF, Johnson K, Chavez RA, Leinwand LA, Watkins LR

Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.

Molecular pain

Milligan ED, Sloane EM, Langer SJ, Cruz PE, Chacur M, Spataro L, Wieseler-Frank J, Hammack SE, Maier SF, Flotte TR, Forsayeth JR, Leinwand LA, Chavez R, Watkins LR

Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV.

Molecular therapy : the journal of the American Society of Gene Therapy

Sanftner LM, Suzuki BM, Doroudchi MM, Feng L, McClelland A, Forsayeth JR, Cunningham J

Acetylcholine receptors are required for agrin-induced clustering of postsynaptic proteins.

The EMBO journal

Marangi PA, Forsayeth JR, Mittaud P, Erb-Vögtli S, Blake DJ, Moransard M, Sander A, Fuhrer C

Pharmacological differences between immunoisolated native brain and heterologously expressed rat alpha4beta2 nicotinic receptors.

Brain research. Molecular brain research

Truong A, Xing X, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN

UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein.

Brain research

Fitzgerald J, Kennedy D, Viseshakul N, Cohen BN, Mattick J, Bateman JF, Forsayeth JR

Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5.

Anesthesiology

Gray AT, Zhao BB, Kindler CH, Winegar BD, Mazurek MJ, Xu J, Chavez RA, Forsayeth JR, Yost CS

Multistep expression and assembly of neuronal nicotinic receptors is both host-cell- and receptor-subtype-dependent.

Brain research. Molecular brain research

Sweileh W, Wenberg K, Xu J, Forsayeth J, Hardy S, Loring RH

Pharmacological similarities between native brain and heterologously expressed alpha4beta2 nicotinic receptors.

British journal of pharmacology

Shafaee N, Houng M, Truong A, Viseshakul N, Figl A, Sandhu S, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN

Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology

Wang N, Verna L, Hardy S, Forsayeth J, Zhu Y, Stemerman MB

TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family.

The Journal of biological chemistry

Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS

Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response.

The Journal of physiology

Figl A, Viseshakul N, Shafaee N, Forsayeth J, Cohen BN

TOK1 is a volatile anesthetic stimulated K+ channel.

Anesthesiology

Gray AT, Winegar BD, Leonoudakis DJ, Forsayeth JR, Yost CS

An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, Yost CS

Detection of mycoplasma infection of mammalian cells.

BioTechniques

Xia H, Fitzgerald J, Bredt DS, Forsayeth JR

Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Forsayeth JR, Kobrin E

A recombinant adenovirus that directs secretion of biologically active kappa-bungarotoxin from mammalian cells.

Brain research. Molecular brain research

Gorman S, Viseshakul N, Cohen B, Hardy S, Grant GA, Yost CS, Forsayeth JR

Intraluminal water increases expression of plasmid DNA in rat lung.

Human gene therapy

Sawa T, Miyazaki H, Pittet JF, Widdicombe JH, Gropper MA, Hashimoto S, Conrad DJ, Folkesson HG, Debs R, Forsayeth JR, Fox B, Wiener-Kronish JP

Adenovirus-mediated transfection of cultured cells.

BioTechniques

Forsayeth JR, Garcia PD

Assembly of the mammalian muscle acetylcholine receptor in transfected COS cells.

The Journal of cell biology

Gu Y, Forsayeth JR, Verrall S, Yu XM, Hall ZW

Expression of functional mouse muscle acetylcholine receptors in Chinese hamster ovary cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Forsayeth JR, Franco A, Rossi AB, Lansman JB, Hall ZW

Properties of embryonic and adult muscle acetylcholine receptors transiently expressed in COS cells.

Neuron

Gu Y, Franco A, Gardner PD, Lansman JB, Forsayeth JR, Hall ZW

Clusters of 43-kDa protein are absent from genetic variants of C2 muscle cells with reduced acetylcholine receptor expression.

Developmental biology

LaRochelle WJ, Ralston E, Forsayeth JR, Froehner SC, Hall ZW

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.

Proceedings of the National Academy of Sciences of the United States of America

Forsayeth JR, Caro JF, Sinha MK, Maddux BA, Goldfine ID

Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.

The Journal of biological chemistry

Forsayeth JR, Montemurro A, Maddux BA, DePirro R, Goldfine ID

Biosynthesis and processing of the human insulin receptor.

Diabetes

Forsayeth J, Maddux B, Goldfine ID

Effects of hyperosmolarity on basal and insulin-stimulated muscle sugar transport.

The American journal of physiology

Forsayeth J, Gould MK